Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | HPGD | P15428 | 5/20 | 0.77 |
| ▸ | NPC1 | O15118 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | TP53 | P04637 | 4/20 | 0.77 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | CASP3 | P42574 | 1/20 | 0.77 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.77 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.77 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.77 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.69 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.69 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31741263 | 0.87 | MAPT (1.00) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL311405 | 0.87 | MAPT (1.00) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL12941631 | 0.82 | NPC1 (0.77) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL5433487 | 0.82 | CSNK2A2 (1.00) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL10144254 | 0.82 | MAPT (0.77) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL15232231 | 0.82 | GABRP (0.82) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL4988784 | 0.82 | MAPT (0.77) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL4991516 | 0.81 | APP (1.00) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL4985743 | 0.81 | APP (1.00) | APPMAPTCYP3A4HPGDNPC1 | |
| SCHEMBL4983190 | 0.81 | APP (1.00) | APPMAPTCYP3A4HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8192717-B2 | Flavone derivative, chalcone derivative, styrylchromone derivative, or a coumarin derivative with high binding specificity to an amyloid beta protein, high permeability to a blood-brain barrier, and ability to rapidly disappear from sites other than cerebral senile plaque; also drug screening | NAGASAKI UNIVERSITY (JP) | 2012-06-05 | — | — | US | disclosed |
| US-20080131367-A1 | Composition For Diagnosing Amyloid-Related Diseases | Mori, Hiroshi (JP) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080131367-A1 | Composition For Diagnosing Amyloid-Related Diseases | APP, APBA1, FABP7 | APP 1/4885MAPT 20/4885CYP3A4 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.