Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 5/20 | 1.00 |
| ▸ | CSNK2B | P67870 | 5/20 | 1.00 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | HPGD | P15428 | 5/20 | 0.77 |
| ▸ | TP53 | P04637 | 4/20 | 0.77 |
| ▸ | NPC1 | O15118 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | CASP3 | P42574 | 1/20 | 0.77 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.77 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.77 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10305788 | 0.91 | CSNK2A2 (1.00) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL10024074 | 0.91 | CSNK2A2 (0.82) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL31741263 | 0.87 | MAPT (1.00) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL311405 | 0.87 | MAPT (1.00) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL4650552 | 0.85 | CSNK2A2 (0.74) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| 6-Methylflavone SCHEMBL4648879 | 0.84 | TP53 (1.00) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| 6-Methylflavone SCHEMBL29804485 | 0.84 | TP53 (1.00) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL28043561 | 0.84 | CSNK2A2 (0.72) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL5424662 | 0.84 | CYP3A4 (0.79) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL535143 | 0.82 | KCNA5 (1.00) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111039910-A | Photoinitiated method for synthesizing 3-aryl flavone or coumarin compound and application thereof | 云南大学 | 2020-04-21 | — | — | CN | disclosed |
| US-10208025-B2 | Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2019-02-19 | — | — | US | disclosed |
| US-9611256-B2 | Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-04-04 | — | — | US | disclosed |
| US-20170044141-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-02-16 | — | — | US | disclosed |
| US-20150011513-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2015-01-08 | — | — | US | disclosed |
| WO-2013127361-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2013-09-06 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | CSNK2A2 1259/4885CSNK2B 874/4885CSNK2A1 1238/4885 |
| US-20170044141-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | ABCG2, ABCB1, ABCC1 | CSNK2A2 4178/4885CSNK2B 4083/4885CSNK2A1 4214/4885 |
| US-10208025-B2 | Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers | ABCG2, ABCB1, ABCC1 | CSNK2A2 4178/4885CSNK2B 4083/4885CSNK2A1 4214/4885 |
| US-20150011513-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | ABCG2, ABCB1, ABCC1 | CSNK2A2 4178/4885CSNK2B 4083/4885CSNK2A1 4214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.