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SCHEMBL10144353

SCHEMBL10144353

FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ GALR2 O43603 14/20 1.00
▸ GALR1 P47211 9/20 0.83
▸ NPSR1 Q6W5P4 1/20 0.51
▸ LMNA P02545 1/20 0.49
▸ TAAR1 Q96RJ0 2/20 0.46
▸ GAA P10253 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10144390 0.88 GALR2 (0.81) GALR2GALR1TAAR1
SCHEMBL10143587 0.85 GALR2 (0.82) GALR2GALR1TAAR1KMT2A
SCHEMBL10143796 0.84 GALR2 (1.00) GALR2GALR1NPSR1LMNATAAR1
SCHEMBL10143797 0.83 GALR2 (0.83) GALR2GALR1NPSR1LMNA
SCHEMBL10144350 0.81 GALR2 (0.72) GALR2GALR1NPSR1LMNATAAR1
SCHEMBL10143793 0.79 GALR2 (1.00) GALR2GALR1NPSR1MAPT
SCHEMBL10143418 0.77 GALR2 (0.86) GALR2GALR1NPSR1LMNATAAR1
SCHEMBL10144392 0.77 GALR2 (1.00) GALR2GALR1NPSR1LMNATAAR1
SCHEMBL10143563 0.76 GALR2 (1.00) GALR2GALR1NPSR1MAPTKMT2A
SCHEMBL10143395 0.76 GALR2 (0.64) GALR2GALR1NPSR1LMNATAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012009258-A2 PEPTIDOMIMETIC GALANIN RECEPTOR MODULATORS ROBERTS EDWARD (US) 2012-01-19 — — WO disclosed