SCHEMBL10145168

SCHEMBL10145168

CC(c1ccc(C(C)c2ccc(N(C)Cc3ccccc3)cc2)cc1)c1ccc(N(C)Cc2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.51
NR1H3 Q13133 1/20 0.51
CRHBP P24387 1/20 0.50
CRHR2 Q13324 1/20 0.50
TSHR P16473 3/20 0.47
ALDH1A1 P00352 1/20 0.47
ADRA2B P18089 1/20 0.46
ADRA2C P18825 1/20 0.46
SLC6A2 P23975 1/20 0.46
HTR2A P28223 1/20 0.46
SLC6A4 P31645 1/20 0.46
ADRA1A P35348 1/20 0.46
OPRK1 P41145 1/20 0.46
SLC6A3 Q01959 1/20 0.46
KCNH2 Q12809 1/20 0.46
AOC3 Q16853 1/20 0.44
GRM2 Q14416 1/20 0.44
CYP2C19 P33261 1/20 0.43
CNR2 P34972 2/20 0.41
IP6K1 Q92551 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25839380 0.89 NR1H2 (0.51) NR1H2NR1H3CRHBPCRHR2TSHR
SCHEMBL11881187 0.86 NR1H2 (0.62) NR1H2NR1H3CRHBPCRHR2TSHR
SCHEMBL5949383 0.83 CYP2C19 (0.63) NR1H2NR1H3CRHBPCRHR2TSHR
SCHEMBL10779746 0.83 CYP2C19 (0.63) NR1H2NR1H3CRHBPCRHR2TSHR
SCHEMBL9626369 0.82 NR1H2 (0.49) NR1H2NR1H3CRHBPCRHR2TSHR
SCHEMBL9626886 0.82 NR1H2 (0.49) NR1H2NR1H3CRHBPCRHR2TSHR
SCHEMBL642317 0.82 CRHBP (0.61) NR1H2NR1H3CRHBPCRHR2TSHR
Hydrochloric Acid SCHEMBL27388371 0.80 CRHBP (0.59) NR1H2NR1H3CRHBPCRHR2TSHR
SCHEMBL4428266 0.79 TSHR (0.70) NR1H2NR1H3TSHRALDH1A1GRM2
SCHEMBL4403042 0.79 NR1H2 (0.56) NR1H2NR1H3CRHBPCRHR2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8178266-B2 Electrophotographic photoreceptor, image forming apparatus using the electrophotographic photoreceptor, and method of producing electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2012-05-15 US disclosed
US-8173343-B2 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH COMPANY, LTD. (JP) 2012-05-08 US disclosed
US-20100015538-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS USING THE SAME, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2010-01-21 US disclosed
US-20090324281-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS USING THE ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTORECEPTOR RICOH COMPANY, LTD. (JP) 2009-12-31 US disclosed