Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 15/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146635 | 0.84 | GRM2 (0.62) | PARGGRM2MAPK14 | |
| SCHEMBL14992923 | 0.83 | PARG (0.48) | PARGGRM2 | |
| SCHEMBL10145948 | 0.82 | GRM2 (0.49) | GRM2METAP2MAPK14CHEK1 | |
| SCHEMBL10145941 | 0.80 | GRM2 (0.47) | GRM2METAP2MAPK14CHEK1 | |
| SCHEMBL10146668 | 0.80 | GRM2 (0.70) | PARGGRM2METAP2 | |
| SCHEMBL10146676 | 0.80 | GRM2 (0.47) | PARGGRM2METAP2MAPK14CHEK1 | |
| SCHEMBL10145950 | 0.79 | MAPK14 (0.53) | GRM2METAP2MAPK14CHEK1 | |
| SCHEMBL10146572 | 0.79 | PARG (0.48) | PARGGRM2 | |
| SCHEMBL10145837 | 0.78 | PARG (0.42) | PARGGRM2 | |
| SCHEMBL10145952 | 0.78 | GRM2 (0.45) | GRM2METAP2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |