Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 6/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627459 | 0.84 | PARG (0.44) | PARGGRIN1GRIN2BGRM2CRHR1 | |
| SCHEMBL10145982 | 0.81 | PARG (0.49) | PARGGRIN1GRIN2BGRM2IRAK4 | |
| SCHEMBL10146644 | 0.80 | GRM2 (0.52) | GRIN1GRIN2BGRM2IRAK4 | |
| SCHEMBL10146576 | 0.79 | GRM2 (0.64) | PARGGRIN1GRIN2BGRM2CRHR1 | |
| SCHEMBL10146339 | 0.76 | PARG (0.43) | PARGGRIN1GRIN2BGRM2CRHR1 | |
| SCHEMBL10146345 | 0.75 | PARG (0.42) | PARGGRIN1GRIN2BGRM2 | |
| SCHEMBL628168 | 0.75 | GRM2 (0.49) | PARGGRIN1GRIN2BGRM2CRHR1 | |
| SCHEMBL10145997 | 0.73 | PARG (0.42) | PARGGRIN1GRIN2BGRM2CRHR1 | |
| SCHEMBL10146006 | 0.72 | PARG (0.40) | PARGGRIN1GRIN2BGRM2CRHR1 | |
| SCHEMBL625527 | 0.72 | GRM2 (0.51) | PARGGRIN1GRIN2BGRM2CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |