Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 14/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627472 | 0.84 | GRM2 (0.49) | GRM2GRIN1GRIN2BCYP11B2 | |
| SCHEMBL10146342 | 0.80 | GRM2 (0.47) | GRM2GRIN1GRIN2BCYP11B2 | |
| SCHEMBL10145946 | 0.80 | GRM2 (0.61) | GRM2GRIN1GRIN2BPIK3CDPIK3CA | |
| SCHEMBL10145920 | 0.80 | PARG (0.46) | GRM2GRIN1GRIN2BIRAK4 | |
| SCHEMBL10145982 | 0.79 | PARG (0.49) | GRM2GRIN1GRIN2BIRAK4 | |
| SCHEMBL14991844 | 0.78 | GRM2 (0.65) | GRM2GRIN1GRIN2B | |
| SCHEMBL14992292 | 0.77 | GRM2 (0.64) | GRM2PIK3CDPIK3CAPIK3CBMTOR | |
| SCHEMBL10146333 | 0.76 | GRM2 (0.70) | GRM2GRIN1GRIN2B | |
| SCHEMBL10146311 | 0.75 | GRM2 (0.78) | GRM2 | |
| SCHEMBL624936 | 0.75 | GRM2 (0.66) | GRM2CYP11B2PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |