Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 13/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14992395 | 0.84 | PARG (0.47) | PARGGRM2 | |
| SCHEMBL10145920 | 0.81 | PARG (0.46) | PARGGRM2IRAK4GRIN1GRIN2B | |
| SCHEMBL10146635 | 0.80 | GRM2 (0.62) | PARGGRM2 | |
| SCHEMBL10146644 | 0.79 | GRM2 (0.52) | GRM2IRAK4GRIN1GRIN2B | |
| SCHEMBL10146671 | 0.77 | PARG (0.51) | PARGGRM2 | |
| SCHEMBL10146572 | 0.77 | PARG (0.48) | PARGGRM2 | |
| SCHEMBL14992408 | 0.74 | PARG (0.45) | PARGGRM2GRIN1GRIN2B | |
| SCHEMBL14992139 | 0.71 | GRIN1 (0.46) | PARGGRIN1GRIN2B | |
| SCHEMBL10145837 | 0.70 | PARG (0.42) | PARGGRM2 | |
| SCHEMBL14992923 | 0.70 | PARG (0.48) | PARGGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |