Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PPM1B | O75688 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10147748 | 0.91 | NPC1 (0.48) | NPC1POLBPPM1BCHRNB2CHRNA5 | |
| SCHEMBL6974214 | 0.85 | NPC1 (0.47) | NPC1POLBPPM1BCHRNB2CHRNA5 | |
| SCHEMBL10147766 | 0.82 | ALDH1A1 (0.36) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL10147727 | 0.76 | CHRNB2 (0.39) | NPC1PPM1BCHRNB2CHRNA5CHRNA7 | |
| SCHEMBL10147728 | 0.76 | ALDH1A1 (0.42) | NPC1POLBPPM1BCHRNB2CHRNA5 | |
| SCHEMBL4858609 | 0.75 | NPC1 (0.49) | NPC1POLBPPM1BCHRNB2CHRNA5 | |
| SCHEMBL5385400 | 0.75 | NPC1 (0.49) | NPC1POLBPPM1BCHRNB2CHRNA5 | |
| SCHEMBL4613728 | 0.75 | NPC1 (0.49) | NPC1POLBPPM1BCHRNB2CHRNA5 | |
| SCHEMBL14593729 | 0.75 | NPC1 (0.49) | NPC1POLBPPM1BCHRNB2CHRNA5 | |
| SCHEMBL13871567 | 0.75 | NPC1 (0.49) | NPC1POLBPPM1BCHRNB2CHRNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097718-B2 | 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof | ANADYS PHARMACEUTICALS, INC. (US) | 2012-01-17 | — | — | US | disclosed |