Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 12/20 | 0.38 |
| ▸ | DRD3 | P35462 | 12/20 | 0.38 |
| ▸ | HTR2A | P28223 | 9/20 | 0.38 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761681 | 0.83 | CNR2 (0.38) | CNR1CNR2 | |
| SCHEMBL12094075 | 0.77 | NPSR1 (0.42) | MAPTDRD2DRD3HTR2AHTR1A | |
| SCHEMBL12094076 | 0.77 | RAB9A (0.48) | MAPTNPC1RAB9A | |
| SCHEMBL10148045 | 0.76 | POLB (0.34) | MAPTDRD2DRD3HTR2AHTR1A | |
| SCHEMBL4761695 | 0.76 | MEN1 (0.39) | MAPTDRD2DRD3HTR2AHTR1A | |
| SCHEMBL10132074 | 0.75 | SMN1; SMN2 (0.52) | MAPTCNR1CNR2SMYD3 | |
| SCHEMBL25030885 | 0.74 | NPSR1 (0.40) | MAPTDRD2DRD3HTR2AHTR1A | |
| SCHEMBL26062862 | 0.74 | NPSR1 (0.40) | MAPTDRD2DRD3HTR2AHTR1A | |
| SCHEMBL23135471 | 0.73 | NPSR1 (0.53) | MAPTDRD2DRD3HTR2AHTR1A | |
| SCHEMBL25029638 | 0.72 | MME (0.40) | MAPTDRD2DRD3HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227555-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS (US) | 2012-07-24 | — | — | US | disclosed |
| US-8106131-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS (US) | 2012-01-31 | — | — | US | disclosed |
| US-20090012241-A1 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-01-08 | — | — | US | disclosed |
| US-7432331-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432330-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |