Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DRD3 | P35462 | 4/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | DRD4 | P21917 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761730 | 0.87 | POLB (0.33) | POLBALDH1A1NPSR1DRD2NPC1 | |
| SCHEMBL10148018 | 0.76 | MAPT (0.40) | DRD2DRD3HTR1ADRD4HTR2B | |
| SCHEMBL10148036 | 0.74 | DRD2 (0.36) | POLBALDH1A1NPSR1DRD2NPC1 | |
| SCHEMBL10148049 | 0.72 | DRD2 (0.36) | POLBALDH1A1NPSR1DRD2SMN1; SMN2 | |
| SCHEMBL12094076 | 0.71 | RAB9A (0.48) | NPSR1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL12094075 | 0.69 | NPSR1 (0.42) | ALDH1A1NPSR1DRD2DRD3HTR1A | |
| SCHEMBL10132074 | 0.67 | SMN1; SMN2 (0.52) | ALDH1A1NPSR1SMN1; SMN2MAPT | |
| SCHEMBL4761690 | 0.66 | BTK (0.42) | NPSR1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL25030885 | 0.66 | NPSR1 (0.40) | ALDH1A1NPSR1DRD2DRD3HTR1A | |
| SCHEMBL26062862 | 0.66 | NPSR1 (0.40) | ALDH1A1NPSR1DRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106131-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS (US) | 2012-01-31 | — | — | US | disclosed |
| US-20090012241-A1 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-01-08 | — | — | US | disclosed |
| US-7432330-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432331-B2 | Hydrolytically stable maleimide-terminated polymers | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |