Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10148187 | 0.92 | ALDH1A1 (0.46) | ALDH1A1KDM4EPOLBEPHX2TSHR | |
| SCHEMBL10185032 | 0.87 | ALDH1A1 (0.42) | ALDH1A1KDM4EPOLBEPHX2TSHR | |
| SCHEMBL10148067 | 0.86 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBSHMT2TSHR | |
| SCHEMBL10148310 | 0.86 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBSHMT2TSHR | |
| SCHEMBL10148076 | 0.85 | POLB (0.47) | ALDH1A1KDM4EPOLBSHMT2TSHR | |
| SCHEMBL661703 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4EPOLBSHMT2TSHR | |
| SCHEMBL661702 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4EPOLBSHMT2TSHR | |
| SCHEMBL10148190 | 0.84 | ALDH1A1 (0.45) | ALDH1A1KDM4EPOLBSHMT2TSHR | |
| SCHEMBL664684 | 0.83 | TSHR (0.45) | ALDH1A1KDM4EPOLBSHMT2TSHR | |
| SCHEMBL664683 | 0.83 | TSHR (0.45) | ALDH1A1KDM4EPOLBSHMT2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
| WO-2010122968-A1 | DIACYLETHYLENEDIAMINE COMPOUND | アステラス製薬株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | ALDH1A1 963/4885KDM4E 3060/4885POLB 3114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.