Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12145732 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL13762559 | 0.80 | CUL4A (0.44) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL6098707 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL4505615 | 0.79 | HPGD (0.43) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL5115492 | 0.79 | HPGD (0.43) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL12145734 | 0.79 | HPGD (0.40) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL13209735 | 0.76 | HPGD (0.41) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL13762561 | 0.76 | KIF11 (0.41) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL4488811 | 0.74 | HPGD (0.42) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL10803023 | 0.71 | HPGD (0.45) | ALDH1A1HPGDTSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169282-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| US-9169282-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| US-9040706-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-8907092-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-20120270886-A1 | INHIBITORS OF IAP | KOEHLER MICHAEL F T (US) | 2012-10-25 | — | — | US | disclosed |
| US-8247557-B2 | IAP inhibitors | GENENTECH, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20110284799-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-11-24 | — | — | US | disclosed |
| US-20110284799-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-11-24 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20110218211-A1 | AZAINDOLE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20110077265-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-03-31 | — | — | US | disclosed |
| US-20110046066-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| WO-2010086089-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2010-08-05 | — | — | WO | disclosed |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH INC. (US) | 2010-05-27 | — | — | US | disclosed |
| US-20090318409-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090221630-A1 | IAP INHIBITORS | GENENTECH, INC. | 2009-09-03 | — | — | US | disclosed |
| US-20090176822-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221630-A1 | IAP INHIBITORS | XIAP, BIRC5, BIRC3 | SMN1; SMN2 2369/4885ALDH1A1 4440/4885HPGD 4452/4885 |
| US-20090176822-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | SMN1; SMN2 2913/4885ALDH1A1 4197/4885HPGD 3158/4885 |
| US-20110284799-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | SMN1; SMN2 3736/4885ALDH1A1 3721/4885HPGD 3882/4885 |
| US-20110046066-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | SMN1; SMN2 2624/4885ALDH1A1 4236/4885HPGD 4110/4885 |
| US-20120270886-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | SMN1; SMN2 2250/4885ALDH1A1 4536/4885HPGD 4547/4885 |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | SMN1; SMN2 2109/4885ALDH1A1 4176/4885HPGD 3736/4885 |
| US-20110218211-A1 | AZAINDOLE INHIBITORS OF IAP | XIAP, BIRC5, API5 | SMN1; SMN2 2777/4885ALDH1A1 3906/4885HPGD 4384/4885 |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | SMN1; SMN2 2109/4885ALDH1A1 4176/4885HPGD 3736/4885 |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | SMN1; SMN2 2913/4885ALDH1A1 4197/4885HPGD 3158/4885 |
| US-20090318409-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | SMN1; SMN2 2913/4885ALDH1A1 4197/4885HPGD 3158/4885 |
| US-20110077265-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC2 | SMN1; SMN2 1078/4885ALDH1A1 4304/4885HPGD 3627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.