Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.44 |
| ▸ | GABRE | P78334 | 2/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165801 | 0.90 | OPRK1 (0.52) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL13948824 | 0.84 | OPRK1 (0.51) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL10149904 | 0.83 | LMNA (0.37) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL10149039 | 0.79 | OPRK1 (0.61) | OPRK1LMNAPDE4DGABRPGABRD | |
| SCHEMBL3287864 | 0.78 | OPRK1 (0.74) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL5017864 | 0.78 | OPRK1 (0.74) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL12356945 | 0.77 | GABRP (0.46) | OPRK1LMNAPDE3AGABRPGABRD | |
| SCHEMBL5619577 | 0.73 | HDAC3 (0.54) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL4824229 | 0.72 | OPRK1 (0.51) | OPRK1LMNAPDE3APDE4DHTR2B | |
| SCHEMBL8672696 | 0.71 | OPRK1 (0.53) | OPRK1LMNAPDE3APDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2422788-A2 | Benzodiazepines and compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2007053193-A2 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-10 | — | — | WO | disclosed |