Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 3/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646969 | 0.91 | MEN1 (0.44) | RXFP1HPGDSHSP90AA1HSP90AB1HSD17B10 | |
| SCHEMBL10151709 | 0.91 | RXRA (0.38) | HPGDSRXRAHSP90AA1HSP90AB1HSD17B10 | |
| SCHEMBL646580 | 0.88 | DEGS1 (0.45) | RXFP1HPGDSMEN1POLBKMT2A | |
| SCHEMBL648016 | 0.87 | LIPE (0.43) | HPGDSSCDKDM4EDEGS1MAPT | |
| SCHEMBL648289 | 0.86 | MAPT (0.43) | RXFP1HPGDSRXRACYP1A2CYP2C19 | |
| SCHEMBL646832 | 0.86 | NPC1 (0.47) | HSD17B10CYP1A2CYP2C19MEN1POLB | |
| SCHEMBL648772 | 0.86 | F10 (0.42) | HPGDSCYP1A2CYP2C19MEN1POLB | |
| SCHEMBL646827 | 0.86 | MAPT (0.41) | RXFP1HPGDSRXRAMEN1POLB | |
| SCHEMBL645596 | 0.86 | MEN1 (0.44) | RXFP1HPGDSMEN1POLBKMT2A | |
| SCHEMBL8234419 | 0.86 | DEGS1 (0.47) | HPGDSRXRAMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |