Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10151397 | 0.91 | RXFP1 (0.37) | RXRAHPGDSSCDPOLBMEN1 | |
| SCHEMBL646580 | 0.88 | DEGS1 (0.45) | ABL1HPGDSPOLBMEN1KMT2A | |
| SCHEMBL646827 | 0.88 | MAPT (0.41) | RXRAABL1HPGDSPOLBMEN1 | |
| SCHEMBL648016 | 0.87 | LIPE (0.43) | HPGDSSCDKDRDEGS1MAPT | |
| SCHEMBL646969 | 0.86 | MEN1 (0.44) | HPGDSSCDPOLBMEN1KMT2A | |
| SCHEMBL646803 | 0.86 | MEN1 (0.46) | SCDPOLBMEN1KMT2ARAB9A | |
| SCHEMBL645596 | 0.86 | MEN1 (0.44) | ABL1HPGDSSCDPOLBMEN1 | |
| SCHEMBL646906 | 0.86 | HPGDS (0.40) | RXRAABL1HPGDSKDRDEGS1 | |
| SCHEMBL646832 | 0.86 | NPC1 (0.47) | ABL1SCDPOLBMEN1KMT2A | |
| SCHEMBL648772 | 0.86 | F10 (0.42) | HPGDSPOLBMEN1KMT2ADEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |