Sugi Predict

Sugi Predict / Compounds / SCHEMBL10153533

SCHEMBL10153533

SCHEMBL10153533

FC(F)(F)C(c1ccc2c(c1)c1cccc3c4ccccc4n2c31)(c1ccc2c(c1)c1cncc3c4cnccc4n2c31)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 4/20 0.39
▸ MAOB P27338 4/20 0.39
▸ ACHE P22303 1/20 0.39
▸ CYP2D6 P10635 1/20 0.34
▸ PGR P06401 2/20 0.32
▸ DDB1 Q16531 1/20 0.32
▸ CRBN Q96SW2 1/20 0.32
▸ NR1H3 Q13133 1/20 0.32
▸ KIF11 P52732 1/20 0.32
▸ HDAC3 O15379 1/20 0.31
▸ HDAC2 Q92769 1/20 0.31
▸ HDAC6 Q9UBN7 1/20 0.31
▸ CYP19A1 P11511 3/20 0.31
▸ CYP2C9 P11712 3/20 0.31
▸ CYP11B1 P15538 3/20 0.31
▸ CYP11B2 P19099 3/20 0.31
▸ TOP2A P11388 1/20 0.30
▸ ELANE P08246 1/20 0.30
▸ RORA P35398 2/20 0.30
▸ RORC P51449 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16656735 0.79 MAOA (0.56) MAOAMAOBACHECYP2D6DDB1
SCHEMBL10153918 0.76 MAOA (0.47) MAOAMAOBACHECYP2D6DDB1
SCHEMBL17265106 0.75 MAOA (0.43) MAOAMAOBACHECYP2D6DDB1
SCHEMBL16656736 0.75 MAOA (0.51) MAOAMAOBACHECYP2D6DDB1
SCHEMBL21889254 0.75 MAOA (0.42) MAOAMAOBACHECYP2D6DDB1
SCHEMBL10153679 0.74 PGR (0.32) PGRNR1H3RORARORCRORB
SCHEMBL10153537 0.74 MAOA (0.40) MAOAMAOBACHECYP2D6DDB1
SCHEMBL10153503 0.74 MAOA (0.44) MAOAMAOBACHECYP2D6DDB1
SCHEMBL261854 0.74 MAOA (0.44) MAOAMAOBACHECYP2D6DDB1
SCHEMBL4570446 0.74 MAOA (0.44) MAOAMAOBACHECYP2D6DDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8421066-B2 Organic electroluminescence device UDC IRELAND LIMITED (IE) 2013-04-16 — — US disclosed
US-8421066-B2 Organic electroluminescence device UDC IRELAND LIMITED (IE) 2013-04-16 — — US disclosed
US-20120178928-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2012-07-12 — — US disclosed
US-20120178928-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2012-07-12 — — US disclosed
US-8174002-B2 Organic electroluminescence device FUJIFILM CORPORATION (JP) 2012-05-08 — — US disclosed
US-8174002-B2 Organic electroluminescence device FUJIFILM CORPORATION (JP) 2012-05-08 — — US disclosed
US-20100051928-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2010-03-04 — — US disclosed
US-20100051928-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2010-03-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100051928-A1 ORGANIC ELECTROLUMINESCENCE DEVICE L1CAM, CHRM1, LEF1 MAOA 1485/4885MAOB 1553/4885ACHE 1356/4885
US-20120178928-A1 ORGANIC ELECTROLUMINESCENCE DEVICE L1CAM, CHRM1, LEF1 MAOA 1485/4885MAOB 1553/4885ACHE 1356/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.