Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959297 | 0.86 | HDAC4 (0.49) | KCNA5MAPTMEN1KMT2ATSHR | |
| SCHEMBL9960452 | 0.84 | KCNA5 (0.46) | KCNA5MAPTMEN1KMT2A | |
| SCHEMBL9959313 | 0.84 | KCNA5 (0.48) | KCNA5MAPTMEN1KMT2APOLB | |
| SCHEMBL9958850 | 0.84 | MEN1 (0.43) | KCNA5MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL10153642 | 0.83 | KCNA5 (0.42) | KCNA5MAPTMEN1KMT2ATSHR | |
| SCHEMBL11787179 | 0.83 | MEN1 (0.47) | MAPTMEN1KMT2ATSHRPOLB | |
| SCHEMBL9958546 | 0.83 | TSHR (0.48) | MAPTCYP3A4TSHRALDH1A1CYP2C9 | |
| SCHEMBL9958882 | 0.82 | KMT2A (0.46) | KCNA5MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9952002 | 0.81 | MEN1 (0.45) | MAPTMEN1KMT2ATSHRPOLB | |
| SCHEMBL9959558 | 0.81 | KCNA5 (0.46) | KCNA5MAPTMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |