Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 13/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953052 | 0.89 | KCNA5 (0.36) | KCNA5KCNH2MEN1MAPTKMT2A | |
| SCHEMBL9959297 | 0.86 | HDAC4 (0.49) | KCNA5MEN1MAPTKMT2A | |
| SCHEMBL10153637 | 0.84 | KCNA5 (0.42) | KCNA5MEN1MAPTKMT2A | |
| SCHEMBL9959313 | 0.84 | KCNA5 (0.48) | KCNA5MEN1MAPTKMT2A | |
| SCHEMBL9958850 | 0.84 | MEN1 (0.43) | KCNA5MEN1MAPTKMT2A | |
| SCHEMBL10153642 | 0.83 | KCNA5 (0.42) | KCNA5MEN1MAPTKMT2A | |
| SCHEMBL11787179 | 0.83 | MEN1 (0.47) | MEN1MAPTKMT2A | |
| SCHEMBL10153971 | 0.82 | POLB (0.50) | KCNA5MEN1MAPTKMT2A | |
| SCHEMBL9958882 | 0.82 | KMT2A (0.46) | KCNA5KCNH2MEN1MAPTKMT2A | |
| SCHEMBL9952002 | 0.81 | MEN1 (0.45) | MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |