Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGAV | P06756 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959558 | 0.94 | KCNA5 (0.46) | KCNA5LMNAMEN1MAPTKMT2A | |
| SCHEMBL9958824 | 0.94 | ALDH1A1 (0.44) | KCNA5LMNAMEN1MAPTKMT2A | |
| SCHEMBL9959297 | 0.88 | HDAC4 (0.49) | KCNA5MEN1MAPTKMT2APOLB | |
| SCHEMBL9959606 | 0.88 | NPC1 (0.52) | MAPTKMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL10153642 | 0.88 | KCNA5 (0.42) | KCNA5LMNAMEN1MAPTKMT2A | |
| SCHEMBL10154072 | 0.88 | MAPT (0.52) | LMNAMAPTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL10153968 | 0.87 | FAAH (0.39) | KCNA5LMNAMEN1MAPTKMT2A | |
| SCHEMBL9958882 | 0.86 | KMT2A (0.46) | KCNA5LMNAMEN1MAPTKMT2A | |
| SCHEMBL9959312 | 0.86 | DRD2 (0.41) | KCNA5LMNAMEN1MAPTKMT2A | |
| SCHEMBL10153706 | 0.85 | PRMT5 (0.43) | LMNAMEN1MAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |