Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 14/20 | 0.61 |
| ▸ | CA12 | O43570 | 11/20 | 0.61 |
| ▸ | CA1 | P00915 | 11/20 | 0.61 |
| ▸ | CA9 | Q16790 | 11/20 | 0.61 |
| ▸ | CA6 | P23280 | 5/20 | 0.61 |
| ▸ | CA5A | P35218 | 5/20 | 0.61 |
| ▸ | CA7 | P43166 | 5/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.61 |
| ▸ | CA4 | P22748 | 4/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.61 |
| ▸ | CA3 | P07451 | 3/20 | 0.61 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7629070 | 0.87 | SMN1; SMN2 (0.80) | SMN1; SMN2GAACA2CA12CA1 | |
| SCHEMBL687206 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2GAACA2CA12CA1 | |
| SCHEMBL31520571 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2GAACA2CA12CA1 | |
| SCHEMBL8080277 | 0.80 | SMN1; SMN2 (0.70) | SMN1; SMN2GAACA2CA12CA1 | |
| Hydrochloric Acid SCHEMBL5344901 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2GAACA2CA12CA1 | |
| SCHEMBL202948 | 0.79 | CA2 (0.81) | CA2CA12CA1CA9CA6 | |
| SCHEMBL31475667 | 0.79 | CA2 (0.68) | SMN1; SMN2CA2CA12CA1CA9 | |
| SCHEMBL7142664 | 0.79 | CA2 (0.68) | SMN1; SMN2CA2CA12CA1CA9 | |
| SCHEMBL30960 | 0.78 | GAA (1.00) | SMN1; SMN2GAACA2CA12CA1 | |
| SCHEMBL1804982 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2GAACA2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-04-06 | — | — | US | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-109715629-B | Aza-indazole compounds for use in tendon and/or ligament injuries | 诺华股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| US-20120165309-A1 | HETERO RING DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-28 | — | — | US | disclosed |
| EP-2397479-A1 | HETERO RING DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092962-A1 | HETERO RING DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | IL2, PIK3R2, IL2RA | SMN1; SMN2 4237/4885GAA 3043/4885CA2 2309/4885 |
| US-20230104936-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | SMN1; SMN2 1776/4885GAA 2832/4885CA2 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.