Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10276671 | 0.83 | CYP2A6 (0.49) | CYP2A6HCRTR1HCRTR2CYP1A2CYP2D6 | |
| SCHEMBL10154113 | 0.81 | SMN1; SMN2 (0.50) | PARP1CYP2A6CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL19650827 | 0.80 | HCRTR1 (0.44) | PRMT6CYP2A6HCRTR1HCRTR2CTSD | |
| SCHEMBL11990207 | 0.80 | CYP1A2 (0.47) | CYP2A6HCRTR1HCRTR2CTSDCYP1A2 | |
| SCHEMBL17335727 | 0.80 | CTSD (0.49) | HCRTR1HCRTR2CTSDCYP1A2CYP2D6 | |
| SCHEMBL30640531 | 0.80 | CYP2A6 (0.49) | CYP2A6HCRTR1HCRTR2CYP1A2CYP2D6 | |
| SCHEMBL11209168 | 0.80 | CYP2A6 (0.49) | CYP2A6HCRTR1HCRTR2CYP1A2CYP2D6 | |
| SCHEMBL1020541 | 0.80 | LMNA (0.49) | CYP2A6HCRTR1HCRTR2CTSDCYP1A2 | |
| SCHEMBL9454369 | 0.80 | CYP2A6 (0.49) | CYP2A6HCRTR1HCRTR2CTSDCYP1A2 | |
| SCHEMBL11952906 | 0.79 | CYP2A6 (0.45) | CYP2A6HCRTR1HCRTR2CTSDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-28 | — | — | US | disclosed |
| EP-2397479-A1 | HETERO RING DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092962-A1 | HETERO RING DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | IL2, PIK3R2, IL2RA | PRMT6 4271/4885PARP1 2140/4885CYP2A6 3444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.