Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | GRK6 | P43250 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30640531 | 1.00 | CYP2A6 (0.49) | CYP2A6GRK6CFTRCYP11B1CYP11B2 | |
| SCHEMBL1020541 | 0.83 | LMNA (0.49) | CYP2A6GRK6HCRTR1HCRTR2KDM4E | |
| SCHEMBL9454369 | 0.83 | CYP2A6 (0.49) | CYP2A6GRK6HCRTR1HCRTR2KDM4E | |
| SCHEMBL10276671 | 0.83 | CYP2A6 (0.49) | CYP2A6GRK6HCRTR1HCRTR2KDM4E | |
| SCHEMBL11926858 | 0.82 | CYP2A6 (0.62) | CYP2A6GRK6HCRTR1HCRTR2KDM4E | |
| SCHEMBL5252166 | 0.81 | CYP2A6 (0.46) | CYP2A6GRK6HCRTR1HCRTR2KDM4E | |
| SCHEMBL11990207 | 0.81 | CYP1A2 (0.47) | CYP2A6GRK6HCRTR1HCRTR2KDM4E | |
| SCHEMBL10154296 | 0.80 | PRMT6 (0.50) | CYP2A6GRK6HCRTR1HCRTR2KDM4E | |
| SCHEMBL11989511 | 0.80 | CYP2A6 (0.45) | CYP2A6GRK6HCRTR1HCRTR2KDM4E | |
| SCHEMBL11952906 | 0.80 | CYP2A6 (0.45) | CYP2A6GRK6HCRTR1HCRTR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117000047-A | Oxidation-resistant, antibacterial and high-flux reverse osmosis membrane and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| US-10407422-B2 | Triazolopyridine inhibitors of myeloperoxidase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-10 | — | — | US | disclosed |
| US-10316035-B2 | Triazolopyridine inhibitors of myeloperoxidase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-06-11 | — | — | US | disclosed |
| US-20190023701-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL MYERS SQUIBB CO (US) | 2019-01-24 | — | — | US | disclosed |
| US-20180244671-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2018-08-30 | — | — | US | disclosed |
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |
| WO-2017040450-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |
| US-4409388-A | 1,2,4-Triazole derivatives, and their use as antifertility agents | GRUPPO LEPETIT S.P.A. (IT) | 1983-10-11 | — | — | US | disclosed |
| US-4370337-A | 1,2,4-Triazole derivatives as antifertility agents and pharmaceutical compositions containing them | GRUPPO LEPETIT S.P.A. (IT) | 1983-01-25 | — | — | US | disclosed |
| EP-0011129-B1 | NEW 1,2,4-TRIAZOLE DERIVATIVES, A PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GRUPPO LEPETIT S.P.A. (IT) | 1981-11-11 | — | — | EP | disclosed |
| EP-0011129-A1 | New 1,2,4-triazole derivatives, a process for their manufacture and pharmaceutical compositions containing them | GRUPPO LEPETIT S.P.A. (IT) | 1980-05-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316035-B2 | Triazolopyridine inhibitors of myeloperoxidase | EPX, MPO, SERPINB1 | CYP2A6 655/4885GRK6 2260/4885CFTR 590/4885 |
| US-20190023701-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | EPX, MPO, SERPINB1 | CYP2A6 546/4885GRK6 2691/4885CFTR 564/4885 |
| US-20180244671-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | EPX, MPO, SERPINB1 | CYP2A6 655/4885GRK6 2260/4885CFTR 590/4885 |
| US-10407422-B2 | Triazolopyridine inhibitors of myeloperoxidase | EPX, MPO, SERPINB1 | CYP2A6 546/4885GRK6 2691/4885CFTR 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.