Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.58 |
| ▸ | BRD1 | O95696 | 1/20 | 0.58 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.58 |
| ▸ | PKLR | P30613 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | DAGLA | Q9Y4D2 | 10/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557904 | 0.83 | PKM (0.73) | PKMTRIM24BRD1BRPF1PKLR | |
| SCHEMBL639690 | 0.82 | PKM (0.58) | PKMTRIM24BRD1BRPF1PKLR | |
| SCHEMBL30511906 | 0.82 | PKM (0.58) | PKMTRIM24BRD1BRPF1PKLR | |
| SCHEMBL4521621 | 0.82 | PKM (0.58) | PKMTRIM24BRD1BRPF1PKLR | |
| SCHEMBL3776603 | 0.82 | PKM (0.58) | PKMTRIM24BRD1BRPF1PKLR | |
| SCHEMBL8557528 | 0.79 | PKM (0.71) | PKMTRIM24BRD1BRPF1GHSR | |
| SCHEMBL2243703 | 0.76 | PKM (0.53) | PKMTRIM24BRD1BRPF1PKLR | |
| SCHEMBL22062310 | 0.76 | DAGLA (0.54) | PKMTRIM24BRD1BRPF1PKLR | |
| SCHEMBL32664554 | 0.76 | PKM (0.65) | PKMTRIM24BRD1BRPF1PKLR | |
| SCHEMBL9333814 | 0.76 | PKM (0.52) | PKMTRIM24BRD1BRPF1PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-28 | — | — | US | disclosed |
| WO-2010092962-A1 | HETERO RING DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | IL2, PIK3R2, IL2RA | PKM 4499/4885TRIM24 2807/4885BRD1 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.