Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19601273 | 0.89 | POLB (0.39) | POLBALDH1A1PKMSMN1; SMN2LMNA | |
| SCHEMBL835434 | 0.85 | CYP19A1 (0.39) | POLBALDH1A1PKMSMN1; SMN2LMNA | |
| SCHEMBL19287544 | 0.85 | BRD4 (0.37) | POLBBRD4ALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL13318048 | 0.84 | CYP19A1 (0.46) | POLBALDH1A1PKMSMN1; SMN2CYP19A1 | |
| SCHEMBL20288270 | 0.83 | BRD4 (0.34) | POLBBRD4ALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL17190592 | 0.83 | ALDH1A1 (0.39) | POLBALDH1A1PKMSMN1; SMN2CYP19A1 | |
| SCHEMBL25010905 | 0.82 | POLB (0.36) | POLBALDH1A1PKMSMN1; SMN2LMNA | |
| SCHEMBL16307670 | 0.82 | LMNA (0.43) | POLBALDH1A1PKMSMN1; SMN2LMNA | |
| SCHEMBL3018592 | 0.81 | POLB (0.34) | POLBBRD4ALDH1A1PKMCYP19A1 | |
| SCHEMBL14328060 | 0.81 | CYP19A1 (0.49) | POLBALDH1A1PKMSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745335-B2 | N-substituted second generation derivatives of antifungal antibiotic amphotericin B and methods of their preparation and application | BLIRT S.A. (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9745335-B2 | N-substituted second generation derivatives of antifungal antibiotic amphotericin B and methods of their preparation and application | BLIRT S.A. (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9200103-B2 | Functionalized olefin polymers, compositions and articles prepared therefrom, and methods for making the same | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-12-01 | — | — | US | disclosed |
| US-20150291648-A1 | N-SUBSTITUTED SECOND GENERATION DERIVATIVES OF ANTIFUNGAL ANTIBIOTIC AMPHOTERICIN B AND METHODS OF THEIR PREPARATION AND APPLICATION | BLIRT S.A. (PL) | 2015-10-15 | — | — | US | disclosed |
| US-9023939-B2 | Polyolefin compositions and articles prepared therefrom, and methods for making the same | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-05-05 | — | — | US | disclosed |
| US-8981013-B2 | Functionalized olefin polymers, compositions and articles prepared therefrom, and methods for making the same | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-03-17 | — | — | US | disclosed |
| US-8653191-B2 | Polyolefin compositions and articles prepared therefrom, and methods for making the same | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-02-18 | — | — | US | disclosed |
| US-8450430-B2 | Functionalized olefin polymers, compositions and articles prepared therefrom, and method of making the same | DOW GLOBAL TECHNOLOGIES, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| US-20130059989-A1 | Polyolefin Compositions and Articles Prepared Therefrom, and Methods for Making the Same | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-03-07 | — | — | US | disclosed |
| US-8288470-B2 | Polyolefin compositions and articles prepared therefrom, and methods for making the same | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-10-16 | — | — | US | disclosed |
| EP-2125918-B1 | FUNCTIONALIZED OLEFIN POLYMERS, COMPOSITIONS AND ARTICLES PREPARED THEREFROM, AND METHODS FOR MAKING THE SAME | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-06-27 | — | — | EP | disclosed |
| US-20100292403-A1 | POLYOLEFIN COMPOSITIONS AND ARTICLES PREPARED THEREFROM, AND METHODS FOR MAKING THE SAME | DOW GLOBAL TECHNOLOGIES LLC | 2010-11-18 | — | — | US | disclosed |
| US-20100143651-A1 | FUNCTIONALIZED OLEFIN POLYMERS, COMPOSITIONS AND ARTICLES PREPARED THEREFROM, AND METHODS FOR MAKING THE SAME | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100093942-A1 | FUNCTIONALIZED OLEFIN POLYMERS, COMPOSITIONS AND ARTICLES PREPARED THEREFROM, AND METHOD OF MAKING THE SAME | DOW GLOBAL TECHNLOGIES INC. (US) | 2010-04-15 | — | — | US | disclosed |
| US-20100029827-A1 | POLYOLEFIN COMPOSITIONS AND ARTICLES PREPARED THEREFROM, AND METHODS FOR MAKING THE SAME | DOW GLOBAL TECHNOLOGIES INC (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291648-A1 | N-SUBSTITUTED SECOND GENERATION DERIVATIVES OF ANTIFUNGAL ANTIBIOTIC AMPHOTERICIN B AND METHODS OF THEIR PREPARATION AND APPLICATION | ERG28, LSS, NPC1 | POLB 876/4885BRD4 2902/4885ALDH1A1 4308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.