Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26218870 | 0.81 | KDM1A (0.54) | KDM1ALMNATSHRALDH1A1 | |
| SCHEMBL26218874 | 0.80 | KDM1A (0.53) | KDM1ALMNATSHRALDH1A1 | |
| SCHEMBL10155702 | 0.80 | SLC6A3 (0.55) | KDM1ALMNATSHRALDH1A1 | |
| SCHEMBL10184986 | 0.77 | TSHR (0.57) | KDM1ALMNATSHRALDH1A1 | |
| SCHEMBL30492221 | 0.77 | KDM1A (0.50) | KDM1ALMNATSHRALDH1A1 | |
| SCHEMBL6676866 | 0.76 | AKR1C1 (0.57) | KDM1ALMNATSHRALDH1A1 | |
| SCHEMBL2814607 | 0.76 | KDM1A (0.49) | KDM1ALMNATSHRALDH1A1 | |
| SCHEMBL20916724 | 0.76 | KDM1A (0.55) | KDM1ALMNATSHRALDH1A1 | |
| SCHEMBL17109519 | 0.75 | ALDH1A1 (0.47) | LMNAALDH1A1 | |
| SCHEMBL30468156 | 0.75 | KDM1A (0.48) | KDM1ALMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015961-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
| US-20120015961-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015961-A1 | ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | BACE1, BACE2, APP | KDM1A 2122/4885LMNA 3717/4885TSHR 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.