Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015497 | 0.86 | HTR6 (0.45) | HTR6DRD3HRH3DRD2SFRP1 | |
| SCHEMBL1015637 | 0.83 | SFRP1 (0.41) | HTR6SFRP1CCR8 | |
| SCHEMBL1015804 | 0.75 | HTR6 (0.48) | HTR6 | |
| SCHEMBL1015805 | 0.75 | HTR6 (0.48) | HTR6 | |
| SCHEMBL1013506 | 0.73 | HTR6 (0.48) | HTR6DRD4 | |
| SCHEMBL26986820 | 0.70 | SLC18A3 (0.58) | DRD3DRD4DRD2 | |
| SCHEMBL1015495 | 0.69 | SFRP1 (0.51) | HTR6DRD3DRD2SFRP1 | |
| SCHEMBL4078059 | 0.69 | HTR6 (0.45) | HTR6CCR8 | |
| SCHEMBL1012908 | 0.68 | HTR6 (0.41) | HTR6DRD3HRH3DRD2KDM4E | |
| SCHEMBL1016232 | 0.67 | HTR6 (0.40) | HTR6DRD3DRD4DRD2SFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-B1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-12 | — | — | EP | disclosed |
| US-7776910-B2 | Arylsulfonyl pyrrolidines as 5-HT6 inhibitors | ROCHE PALO ALTO LLC (US) | 2010-08-17 | — | — | US | disclosed |