Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16716028 | 0.86 | RAD52 (0.39) | RAD52HTR2AKDM4EALOX12HTT | |
| SCHEMBL10156577 | 0.75 | MAOB (0.60) | KDM4EALOX12HTTNPC1RAB9A | |
| SCHEMBL13283111 | 0.74 | CCR1 (0.45) | RAD52KDM4EHTTNPC1HSP90AA1 | |
| SCHEMBL15703117 | 0.73 | MEN1 (0.50) | KDM4EHTTNPC1NPSR1HSP90AA1 | |
| SCHEMBL15703114 | 0.70 | CCR1 (0.41) | HTTNPC1RAB9AHSP90AA1ALDH1A1 | |
| SCHEMBL10156261 | 0.69 | NSD2 (0.41) | RAD52KDM4EALOX12HTTNPC1 | |
| SCHEMBL10156188 | 0.69 | KDM4E (0.42) | RAD52KDM4EALOX12HTTNPC1 | |
| SCHEMBL10156259 | 0.69 | KDM4E (0.43) | KDM4EALOX12HTTNPC1RAB9A | |
| SCHEMBL10156189 | 0.69 | KDM4E (0.39) | RAD52KDM4EALOX12HTTNPC1 | |
| SCHEMBL23015583 | 0.68 | RAD52 (0.49) | RAD52KDM4EHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9034303-B2 | Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof | ZURAWSKI JR VINCENT R (US) | 2015-05-19 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| WO-2012020389-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | MAOA, MAOB, FECH | RAD52 2498/4885HTR2A 107/4885KDM4E 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.