Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10156261 | 0.86 | NSD2 (0.41) | KDM4EALDH1A1MAPTRXFP1HTT | |
| SCHEMBL10156188 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL620812 | 0.79 | KDM4E (0.57) | KDM4EALDH1A1MAPTRXFP1HTT | |
| SCHEMBL10156263 | 0.78 | PKM (0.43) | KDM4EALDH1A1MAPTRXFP1HTT | |
| SCHEMBL13255403 | 0.77 | CCR1 (0.51) | KDM4EALDH1A1MAPTRXFP1HTT | |
| SCHEMBL15854519 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1MAPTRXFP1HTT | |
| SCHEMBL12020186 | 0.76 | CCR1 (0.50) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL13255406 | 0.75 | NQO2 (0.43) | KDM4EALDH1A1MAPTRXFP1HTT | |
| SCHEMBL10692355 | 0.74 | MAOA (0.55) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL31715248 | 0.74 | L3MBTL1 (0.57) | KDM4EALDH1A1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9034303-B2 | Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof | ZURAWSKI JR VINCENT R (US) | 2015-05-19 | — | — | US | disclosed |
| US-9034303-B2 | Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof | ZURAWSKI JR VINCENT R (US) | 2015-05-19 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| WO-2012020389-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | MAOA, MAOB, FECH | KDM4E 183/4885ALDH1A1 641/4885MAPT 1363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.