Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 6/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13761441 | 0.81 | MAPK14 (0.45) | HPGD | |
| SCHEMBL12826671 | 0.79 | MEN1 (0.49) | HPGDTSHRSMN1; SMN2CA2 | |
| SCHEMBL4141704 | 0.79 | KMT2A (0.56) | HDAC8HDAC6HDAC2PLAUHPGD | |
| SCHEMBL30997032 | 0.79 | NEU3 (0.56) | HDAC8HDAC6HDAC2PLAUHPGD | |
| SCHEMBL22893678 | 0.78 | PARP1 (0.46) | TSHRSMN1; SMN2CA2 | |
| SCHEMBL12218136 | 0.76 | HDAC6 (0.50) | HDAC8HDAC6HDAC2PLAUHPGD | |
| SCHEMBL13513549 | 0.75 | ATM (0.44) | HPGDTSHRHTTSMN1; SMN2 | |
| SCHEMBL12139942 | 0.75 | HPGD (0.43) | HPGDSMN1; SMN2 | |
| SCHEMBL21416718 | 0.75 | PLK1 (0.50) | HPGDTSHRHTTSMN1; SMN2PLK1 | |
| SCHEMBL11959873 | 0.74 | TAS1R3 (0.59) | HDAC8HDAC6HDAC2PLAUHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277425-A1 | TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-01 | — | — | US | disclosed |
| US-20120040968-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | WATERS TECHNOLOGIES CORPORATION (US) | 2012-02-16 | — | — | US | disclosed |
| US-8067417-B2 | Imidazo[1,2-F]pteridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110021519-A1 | TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-27 | — | — | US | disclosed |
| US-7763629-B2 | Tetrahydropteridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-07-27 | — | — | US | disclosed |
| US-20090062292-A1 | Tetrahydropteridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277425-A1 | TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | PRKCH, DMPK, MAP3K20 | HDAC8 4640/4885HDAC6 3294/4885HDAC2 3806/4885 |
| US-20090062292-A1 | Tetrahydropteridines useful as inhibitors of protein kinases | PRKCH, DMPK, MAP3K20 | HDAC8 4640/4885HDAC6 3294/4885HDAC2 3806/4885 |
| US-20110021519-A1 | TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | PRKCH, DMPK, MAP3K20 | HDAC8 4640/4885HDAC6 3294/4885HDAC2 3806/4885 |
| US-20120040968-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | EML4, ALK, ERBB4 | HDAC8 1376/4885HDAC6 677/4885HDAC2 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.