Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24422981 | 0.83 | MAPT (0.58) | ALDH1A1HPGDCYP1A2CYP3A4MAPT | |
| SCHEMBL13219859 | 0.81 | CA12 (0.65) | ALDH1A1CYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL13219861 | 0.81 | ALDH1A1 (0.51) | ALDH1A1HPGDCYP1A2CYP3A4MAPT | |
| SCHEMBL4151619 | 0.81 | CYP1A2 (0.66) | PLK1ALDH1A1HPGDCCNCCDK8 | |
| SCHEMBL14879295 | 0.80 | TSHR (0.46) | ALDH1A1CYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL19519009 | 0.78 | PDE4D (0.60) | PLK1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL12062652 | 0.78 | TAS1R3 (0.60) | PLK1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL30997032 | 0.78 | NEU3 (0.56) | PLK1HPGDPYGLTSHRSMN1; SMN2 | |
| SCHEMBL7984450 | 0.77 | LMNA (0.67) | PLK1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL22516365 | 0.77 | PLK1 (0.53) | PLK1SLC6A2SLC6A4SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |