Sugi Predict

Sugi Predict / Compounds / SCHEMBL1015935

SCHEMBL1015935

SCHEMBL1015935

CC(C)(C)OC(=O)N1CCc2sccc2C1

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ESR2 Q92731 1/20 0.58
▸ NR1H2 P55055 2/20 0.56
▸ MAPK1 P28482 1/20 0.50
▸ PRMT5 O14744 1/20 0.47
▸ WDR77 Q9BQA1 1/20 0.47
▸ HSP90AA1 P07900 1/20 0.47
▸ ADORA1 P30542 2/20 0.47
▸ MAPT P10636 3/20 0.46
▸ KDM4E B2RXH2 1/20 0.46
▸ BRD4 O60885 1/20 0.43
▸ CREBBP Q92793 1/20 0.43
▸ NAMPT P43490 1/20 0.43
▸ SCN9A Q15858 1/20 0.42
▸ GPR119 Q8TDV5 1/20 0.42
▸ KCNQ2 O43526 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3005376 0.90 ESR2 (0.52) ESR2NR1H2MAPK1PRMT5WDR77
SCHEMBL976218 0.89 ESR2 (0.58) ESR2NR1H2MAPK1PRMT5WDR77
SCHEMBL28824366 0.87 ESR2 (0.48) ESR2NR1H2MAPK1ADORA1MAPT
SCHEMBL7795095 0.83 ESR2 (0.49) ESR2NR1H2MAPK1PRMT5WDR77
SCHEMBL24118456 0.79 NAMPT (0.47) ESR2NR1H2PRMT5WDR77KDM4E
SCHEMBL21828511 0.79 NAMPT (0.47) ESR2NR1H2PRMT5WDR77KDM4E
SCHEMBL25382246 0.79 NAMPT (0.47) ESR2NR1H2PRMT5WDR77KDM4E
SCHEMBL7310643 0.79 DRD2 (0.49) PRMT5WDR77KDM4EGPR119
SCHEMBL8680487 0.79 NOTUM (0.57) PRMT5WDR77HSP90AA1KCNQ2
SCHEMBL6421569 0.78 ESR2 (0.55) ESR2NR1H2MAPK1ADORA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4678644-A1 SUBSTITUTED DIHYDROTHIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF Shanghai Yidi Biotechnology Co., Ltd. (CN) 2026-01-14 — — EP disclosed
EP-4665733-A1 AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 Bristol-Myers Squibb Company (US) 2025-12-24 — — EP disclosed
US-12479797-B2 Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors Jubilant Epicore LLC (US) 2025-11-25 — — US disclosed
EP-3455204-B1 CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS Jubilant Epicore LLC (US) 2025-10-29 — — EP disclosed
CN-119768164-A Pharmaceutical compounds for treating complement-mediated disorders 阿雷克森制药公司 2025-04-04 — — CN disclosed
WO-2024213089-A1 SUBSTITUTED DIHYDROTHIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF 上海壹迪生物技术有限公司 2024-10-17 — — WO disclosed
WO-2024173323-A1 AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 BRISTOL-MYERS SQUIBB COMPANY (US) 2024-08-22 — — WO disclosed
CN-116323612-A Tricyclic urea compounds as JAK 2V 617F inhibitors 因赛特公司 2023-06-23 — — CN disclosed
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 — — WO disclosed
US-20220281815-A1 CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS Jubilant Epicore LLC 2022-09-08 — — US disclosed
WO-2007106349-A2 PIPERAZINYL OXOALKYL TETRAHYDROISOQUINOLINES AND RELATED ANALOGUES NEUROGEN CORPORATION (US) 2007-09-20 — — WO disclosed
US-7265128-B2 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes MERCK & CO., INC. (US) 2007-09-04 — — US disclosed
EP-1809619-A1 BISSULFONAMIDE COMPOUNDS AS AGONISTS OF GALR1, COMPOSITIONS, AND METHODS OF USE Transtech Pharma, Inc. (US) 2007-07-25 — — EP disclosed
US-20060106089-A1 Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use VTVX HOLDINGS II LLC 2006-05-18 — — US disclosed
WO-2006047302-A1 BISSULFONAMIDE COMPOUNDS AS AGONISTS OF GALR1, COMPOSITIONS, AND METHODS OF USE TRANSTECH PHARMA, INC. (US) 2006-05-04 — — WO disclosed
US-20060069116-A1 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes MERCK SHARP & DOHME LLC 2006-03-30 — — US disclosed
EP-1057814-B1 TETRAHYDROBENZINDOLE DERIVATIVES MEIJI SEIKA KAISHA (JP) 2005-03-09 — — EP disclosed
US-6498251-B1 Tetrahydrobenzindole derivatives MEIJI SEIKA KAISHA, LTD. (JP) 2002-12-24 — — US disclosed
EP-1057814-A1 TETRAHYDROBENZINDOLE DERIVATIVES Meiji Seika Kaisha, Ltd. (JP) 2000-12-06 — — EP disclosed
US-6015817-A IMIDAZOLE-SUBSTITUTED THIENO(3,2-C)PYRIDINE DERIVATIVES; ANTICARCINOGENIC AGENTS, VIRICIDES; NERVOUS SYSTEM DISORDERS, VISION DEFECTS, KIDNEY DISEASES MERCK & CO., INC. (US) 2000-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060106089-A1 Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use GALR1, GALR3, GALR2 ESR2 539/4885NR1H2 725/4885MAPK1 2039/4885
US-12479797-B2 Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors HDAC1, HDAC11, HDAC2 ESR2 2967/4885NR1H2 323/4885MAPK1 1739/4885
US-20060069116-A1 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes DPP4, DPP3, DPP7 ESR2 3005/4885NR1H2 3748/4885MAPK1 3966/4885
US-20220281815-A1 CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS HDAC1, HDAC11, HDAC2 ESR2 2967/4885NR1H2 323/4885MAPK1 1739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.