Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.41 |
| ▸ | CDK4 | P11802 | 7/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCND2 | P30279 | 2/20 | 0.40 |
| ▸ | CCND3 | P30281 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019273 | 0.85 | SYK (0.56) | SYKCDK4CCND1CDK2CCNE1 | |
| SCHEMBL1018052 | 0.84 | SYK (0.51) | SYKSTAT6LRRK2BRD4FLT3 | |
| SCHEMBL1018466 | 0.82 | PTK2 (0.46) | SYKSTAT6LRRK2BRD4FLT3 | |
| SCHEMBL1017856 | 0.78 | STK17A (0.48) | SYKCDK4STAT6LRRK2CCND1 | |
| SCHEMBL1021379 | 0.76 | SYK (0.51) | SYKLRRK2CDK2CCNA2CCND3 | |
| SCHEMBL1073636 | 0.76 | SYK (0.47) | SYK | |
| SCHEMBL4307181 | 0.74 | SYK (0.51) | SYKCDK4CCND1CDK2CCNE1 | |
| SCHEMBL1070140 | 0.72 | ALK (0.49) | SYKCDK4CCND1CDK2CCNE1 | |
| SCHEMBL7465334 | 0.72 | CDK4 (0.56) | SYKCDK4CCND1CDK2CCNE1 | |
| SCHEMBL7460253 | 0.70 | CDK4 (0.72) | CDK4CCND1CDK2CCNE1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |