Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | WEE1 | P30291 | 3/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 6/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018052 | 0.89 | SYK (0.51) | SYKFLT3LRRK2BTK | |
| SCHEMBL1019473 | 0.84 | ALK (0.66) | SYKJAK2FLT3ALK | |
| SCHEMBL1018497 | 0.81 | SYK (0.45) | SYKJAK2CDK9LRRK2 | |
| SCHEMBL1016206 | 0.80 | TTK (0.49) | SYKEGFRJAK3PTK2BTK | |
| SCHEMBL1018466 | 0.80 | PTK2 (0.46) | SYKFLT3LRRK2PTK2BTK | |
| SCHEMBL1015978 | 0.76 | SYK (0.41) | SYKFLT3CDK9CCNA2CDK2 | |
| SCHEMBL1018605 | 0.74 | FGFR4 (0.42) | SYKFLT3 | |
| SCHEMBL1017856 | 0.74 | STK17A (0.48) | SYKFLT3CCNA2CDK2CCND3 | |
| SCHEMBL1017426 | 0.73 | SYK (0.58) | SYKALK | |
| SCHEMBL1018450 | 0.72 | SYK (0.69) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |