Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018466 | 0.91 | PTK2 (0.46) | SYKNPC1RAB9ASMN1; SMN2LRRK2 | |
| SCHEMBL1021379 | 0.89 | SYK (0.51) | SYKLRRK2FLT3BTK | |
| SCHEMBL1017856 | 0.85 | STK17A (0.48) | SYKNPC1RAB9ASMN1; SMN2LRRK2 | |
| SCHEMBL1015978 | 0.84 | SYK (0.41) | SYKLRRK2STAT6BRD4FLT3 | |
| SCHEMBL1017426 | 0.84 | SYK (0.58) | SYK | |
| SCHEMBL1018497 | 0.81 | SYK (0.45) | SYKLRRK2 | |
| SCHEMBL1016206 | 0.80 | TTK (0.49) | SYKBTK | |
| SCHEMBL1018581 | 0.80 | GSK3A (0.52) | SYKNPC1RAB9ASMN1; SMN2BRD4 | |
| SCHEMBL1017694 | 0.79 | CCNE1 (0.52) | SYKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1018676 | 0.79 | JAK3 (0.57) | SYKNPC1RAB9ASMN1; SMN2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |