Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.48 |
| ▸ | STK17B | O94768 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 6/20 | 0.47 |
| ▸ | CCND1 | P24385 | 5/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | STAT6 | P42226 | 2/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | CCND2 | P30279 | 2/20 | 0.44 |
| ▸ | CCND3 | P30281 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018466 | 0.87 | PTK2 (0.46) | STAT6LRRK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1018052 | 0.85 | SYK (0.51) | STAT6LRRK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4383043 | 0.81 | ALK (0.60) | SYKPTK2 | |
| SCHEMBL27930650 | 0.81 | SYK (0.55) | STK17ASTK17BCDK4CCND1CCNA2 | |
| SCHEMBL1015978 | 0.78 | SYK (0.41) | CDK4CCND1CCNA2CDK2STAT6 | |
| SCHEMBL1021379 | 0.74 | SYK (0.51) | STK17ASTK17BCCNA2CDK2LRRK2 | |
| SCHEMBL2571469 | 0.73 | SYK (0.50) | CDK4CCND1LRRK2FLT3SYK | |
| SCHEMBL1018622 | 0.71 | TTK (0.52) | PTK2 | |
| SCHEMBL13549595 | 0.71 | RAB9A (0.48) | CDK2STAT6LRRK2NPC1RAB9A | |
| SCHEMBL1016309 | 0.71 | TTK (0.51) | PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |