Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22678726 | 1.00 | HTT (0.42) | HTTSMN1; SMN2ATMGAAEPHX1 | |
| SCHEMBL4898829 | 0.88 | HSD17B10 (0.37) | HTTSMN1; SMN2ATMEPHX1DPP4 | |
| SCHEMBL10205021 | 0.88 | HSD17B10 (0.37) | HTTSMN1; SMN2ATMEPHX1DPP4 | |
| SCHEMBL8235608 | 0.88 | HSD17B10 (0.37) | HTTSMN1; SMN2ATMEPHX1DPP4 | |
| SCHEMBL4901400 | 0.86 | EPHX1 (0.35) | HTTSMN1; SMN2ATMEPHX1 | |
| Hydrochloric Acid SCHEMBL7302950 | 0.86 | HSD17B10 (0.36) | HTTSMN1; SMN2ATMEPHX1DPP4 | |
| SCHEMBL19487470 | 0.80 | HTT (0.39) | HTT | |
| SCHEMBL5702246 | 0.80 | LMNA (0.40) | HTTATM | |
| SCHEMBL19271791 | 0.80 | HTT (0.39) | HTT | |
| SCHEMBL5702250 | 0.80 | LMNA (0.40) | HTTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20120115819-A1 | Pentacycline Compounds | TETRAPHASE PHARMACEUTICALS, INC. | 2012-05-10 | — | — | US | disclosed |
| US-20120115819-A1 | Pentacycline Compounds | TETRAPHASE PHARMACEUTICALS, INC. | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | TRPV1, CACNA1G, CACNA1B | HTT 708/4885SMN1; SMN2 1014/4885ATM 4399/4885 |
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | TRPV1, CACNA1G, CACNA1B | HTT 708/4885SMN1; SMN2 1014/4885ATM 4399/4885 |
| US-20120115819-A1 | Pentacycline Compounds | TSLP, IL5, IL17A | HTT 1052/4885SMN1; SMN2 3883/4885ATM 4853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.