Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.86 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 6/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | DDX3X | O00571 | 1/20 | 0.59 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754266 | 0.93 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL1028387 | 0.91 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL1028389 | 0.91 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL13623020 | 0.87 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1026974 | 0.85 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5183414 | 0.84 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL27841700 | 0.84 | MEN1 (0.74) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL28991799 | 0.83 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL8528004 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL1026824 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093266-B2 | Rho kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| US-20100041645-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041645-A1 | RHO KINASE INHIBITORS | CIT, ROCK1, RHOT2 | ALDH1A1 3661/4885SMN1; SMN2 2901/4885MAPT 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.