Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | SERPINE1 | P05121 | 8/20 | 0.60 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.60 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ACLY | P53396 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.54 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988908 | 0.85 | KDM4E (0.70) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL7045036 | 0.85 | KDM4E (1.00) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL7259309 | 0.85 | KDM4E (0.70) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL29183052 | 0.85 | GRIK1 (0.68) | KDM4EALDH1A1 | |
| SCHEMBL11604753 | 0.84 | KDM4E (0.68) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL13460162 | 0.82 | KDM4E (0.66) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL9681911 | 0.82 | KDM4E (0.66) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL27331760 | 0.82 | KDM4E (0.66) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL418999 | 0.82 | KDM4E (0.66) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 | |
| SCHEMBL29293884 | 0.82 | KDM4E (0.71) | KDM4EHSD17B10SERPINE1AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415479-B2 | Inhibitor of plasminogen activator inhibitor-1 | RENASCIENCE CO., LTD. (JP) | 2013-04-09 | — | — | US | disclosed |
| US-20110112140-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | RENASCIENCE CO., LTD. (JP) | 2011-05-12 | — | — | US | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |
| US-4085260-A | Powder coating compositions with hydroxy containing acrylic copolymers-I and carboxylic acid or anhydride crosslinking agent | FORD MOTOR COMPANY (US) | 1978-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112140-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | SERPINE1, SERPINB1, SERPINC1 | KDM4E 4108/4885HSD17B10 1898/4885SERPINE1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.