Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10164594 | 0.93 | L3MBTL1 (0.53) | TSHRL3MBTL1TRPA1MAPTATM | |
| SCHEMBL893508 | 0.92 | TSHR (0.59) | TSHRKDM4ETRPA1ATM | |
| SCHEMBL10164568 | 0.90 | TSHR (0.49) | TSHRKDM4ECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10164574 | 0.88 | TSHR (0.47) | TSHRKDM4ECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10164494 | 0.87 | L3MBTL1 (0.55) | TSHRL3MBTL1TRPA1MAPTATM | |
| SCHEMBL10164495 | 0.87 | L3MBTL1 (0.54) | TSHRL3MBTL1TRPA1MAPTATM | |
| SCHEMBL10164587 | 0.86 | L3MBTL1 (0.49) | TSHRL3MBTL1TRPA1MAPTATM | |
| SCHEMBL10164634 | 0.86 | TSHR (0.67) | TSHRKDM4EL3MBTL1CYP3A4CYP2D6 | |
| SCHEMBL10164510 | 0.85 | L3MBTL1 (0.57) | TSHRL3MBTL1TRPA1MAPTATM | |
| SCHEMBL894169 | 0.85 | TRPA1 (0.51) | TSHRTRPA1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | TSHR 2952/4885KDM4E 4514/4885L3MBTL1 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.