Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893073 | 0.93 | TSHR (0.55) | TSHRKDM4ETRPA1 | |
| SCHEMBL10164691 | 0.93 | L3MBTL1 (0.53) | TSHRKDM4EL3MBTL1TRPA1MAPT | |
| SCHEMBL10164660 | 0.92 | TSHR (0.51) | TSHRL3MBTL1TRPA1MAPTATM | |
| SCHEMBL10164644 | 0.90 | TRPA1 (0.46) | TSHRTRPA1 | |
| SCHEMBL10164675 | 0.88 | L3MBTL1 (0.51) | TSHRL3MBTL1TRPA1MAPTATM | |
| SCHEMBL10164634 | 0.88 | TSHR (0.67) | TSHRKDM4EL3MBTL1TRPA1MAPT | |
| SCHEMBL10164554 | 0.87 | TSHR (0.43) | TSHRTRPA1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10164668 | 0.86 | KDM4E (0.43) | TSHRKDM4EL3MBTL1TRPA1MAPT | |
| SCHEMBL894149 | 0.85 | TRPA1 (0.52) | TSHRTRPA1 | |
| SCHEMBL893968 | 0.85 | TRPA1 (0.52) | TSHRTRPA1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | TSHR 2952/4885KDM4E 4514/4885L3MBTL1 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.