Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10164672 | 0.94 | TRPA1 (0.34) | TRPA1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL893449 | 0.93 | TRPA1 (0.40) | TRPA1 | |
| SCHEMBL10164555 | 0.92 | CYP3A4 (0.35) | TRPA1ALDH1A1LMNARECQLTP53 | |
| SCHEMBL10164538 | 0.89 | ALDH1A1 (0.37) | TRPA1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL894677 | 0.88 | TRPA1 (0.40) | TRPA1EPHX2 | |
| SCHEMBL10164609 | 0.87 | TRPA1 (0.38) | TRPA1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10164663 | 0.87 | TRPA1 (0.45) | TRPA1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL893072 | 0.86 | TRPA1 (0.39) | TRPA1MAPT | |
| SCHEMBL10164684 | 0.86 | TRPA1 (0.42) | TRPA1ALDH1A1TP53 | |
| SCHEMBL10164658 | 0.85 | TRPA1 (0.37) | TRPA1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885ALDH1A1 1469/4885MEN1 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.