Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10164979 | 0.76 | PKM (0.44) | L3MBTL1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL25882415 | 0.75 | MAPT (0.51) | KMT2AMEN1SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL8501054 | 0.74 | GSK3B (0.51) | L3MBTL1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL12481397 | 0.73 | SMN1; SMN2 (0.49) | KMT2AMEN1SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL13212654 | 0.73 | SMN1; SMN2 (0.49) | KMT2AMEN1SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL15334000 | 0.73 | SMN1; SMN2 (0.49) | KMT2AMEN1SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL13406756 | 0.72 | SMN1; SMN2 (0.48) | KMT2AMEN1SMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL25882277 | 0.72 | SMN1; SMN2 (0.48) | KMT2AMEN1SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL19980197 | 0.72 | MEN1 (0.48) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL19980167 | 0.71 | ALDH1A1 (0.50) | RAB9AKMT2AMEN1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293744-B2 | Heterocyclic fused cinnoline M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20120040978-A1 | Heterocyclic Fused Cinnoline M1 Receptor Positive Allosteric Modulators | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040978-A1 | Heterocyclic Fused Cinnoline M1 Receptor Positive Allosteric Modulators | CHRM1, CNR1, CHRNA7 | L3MBTL1 3385/4885MAPK8 3827/4885MAPK9 3100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.