Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008016 | 0.87 | PTGS1 (0.59) | TSHRMEN1MAPTKMT2AHTT | |
| SCHEMBL309863 | 0.87 | LMNA (0.61) | TSHRMEN1MAPTKMT2AHTT | |
| SCHEMBL635130 | 0.80 | TSHR (0.90) | TSHRMEN1KMT2AHTTLMNA | |
| SCHEMBL1097495 | 0.80 | TSHR (1.00) | TSHRMEN1KMT2AHTTLMNA | |
| SCHEMBL16588340 | 0.79 | TSHR (0.59) | TSHRMEN1MAPTKMT2AHTT | |
| SCHEMBL16958006 | 0.79 | TSHR (0.59) | TSHRMEN1MAPTKMT2AHTT | |
| SCHEMBL18677858 | 0.79 | TSHR (0.53) | TSHRMEN1MAPTKMT2ALMNA | |
| SCHEMBL17214759 | 0.79 | TSHR (0.49) | TSHRMEN1MAPTKMT2AHTT | |
| SCHEMBL189811 | 0.78 | MAPT (0.56) | TSHRMEN1MAPTKMT2AHTT | |
| SCHEMBL1689643 | 0.78 | LMNA (0.49) | TSHRMEN1MAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180042908-A1 | PHENYL DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
| US-9820980-B2 | Phenyl derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-11-21 | — | — | US | disclosed |
| US-9676719-B2 | Phenyl derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| US-20160213660-A1 | PHENYL DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2016-07-28 | — | — | US | disclosed |
| US-9340499-B2 | Phenyl derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2016-05-17 | — | — | US | disclosed |
| EP-2900645-A1 | 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION | Bayer CropScience AG (DE) | 2015-08-05 | — | — | EP | disclosed |
| US-20150126486-A1 | PHENYL DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2015-05-07 | — | — | US | disclosed |
| US-8975409-B2 | Phenyl derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2015-03-10 | — | — | US | disclosed |
| US-20140235611-A1 | PHENYL DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-08-21 | — | — | US | disclosed |
| US-20130165440-A1 | JAK1 Inhibitors | EXELIXIS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-8093385-B2 | Leukotriene B4 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20090054466-A1 | Leukotriene B4 Inhibitors | DOMINIQUE ROMYR | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126486-A1 | PHENYL DERIVATIVE | S1PR2, S1PR1, S1PR3 | TSHR 2487/4885MEN1 1038/4885MAPT 4759/4885 |
| US-20090054466-A1 | Leukotriene B4 Inhibitors | LTB4R2, LTB4R, LTC4S | TSHR 2676/4885MEN1 4324/4885MAPT 4334/4885 |
| US-20180042908-A1 | PHENYL DERIVATIVE | S1PR2, S1PR1, S1PR3 | TSHR 2094/4885MEN1 1010/4885MAPT 4752/4885 |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | TSHR 1410/4885MEN1 2485/4885MAPT 3359/4885 |
| US-20160213660-A1 | PHENYL DERIVATIVE | S1PR2, S1PR1, S1PR3 | TSHR 2094/4885MEN1 1010/4885MAPT 4752/4885 |
| US-20140235611-A1 | PHENYL DERIVATIVE | S1PR2, S1PR1, S1PR3 | TSHR 2487/4885MEN1 1038/4885MAPT 4759/4885 |
| US-20130165440-A1 | JAK1 Inhibitors | JAK1, JAK2, JAK3 | TSHR 1965/4885MEN1 1681/4885MAPT 2899/4885 |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | TSHR 681/4885MEN1 2580/4885MAPT 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.