Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 13/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165476 | 0.94 | MMP13 (0.48) | HDAC3HDAC1HDAC2HDAC6MMP13 | |
| SCHEMBL8247704 | 0.91 | MMP13 (0.45) | HDAC3HDAC1HDAC2HDAC6MMP13 | |
| SCHEMBL8256400 | 0.90 | MAPK1 (0.42) | HDAC3HDAC1HDAC2HDAC6MMP13 | |
| SCHEMBL10165461 | 0.85 | MAPK1 (0.46) | HDAC3HDAC1HDAC2HDAC6MMP13 | |
| SCHEMBL4255252 | 0.85 | MMP13 (0.50) | HDAC3HDAC1HDAC2HDAC6MMP13 | |
| SCHEMBL8252066 | 0.84 | MMP13 (0.47) | HDAC3HDAC1HDAC2HDAC6MMP13 | |
| SCHEMBL10165604 | 0.84 | MMP13 (0.46) | HDAC3HDAC1HDAC2HDAC6MMP13 | |
| SCHEMBL10162418 | 0.84 | MMP13 (0.50) | HDAC3HDAC1HDAC2HDAC6MMP13 | |
| SCHEMBL10167899 | 0.82 | MMP13 (0.49) | MMP13MAPK1ADAMTS4MMP3CYP1A1 | |
| SCHEMBL10162378 | 0.81 | MMP13 (0.45) | MMP13MAPK1ADAMTS4MMP3RPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | HDAC3 80/4885HDAC1 104/4885HDAC2 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.