Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.58 |
| ▸ | MMP8 | P22894 | 4/20 | 0.48 |
| ▸ | MMP10 | P09238 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8258270 | 0.94 | MMP13 (0.61) | MMP13MMP8MMP10MMP9HCRTR1 | |
| SCHEMBL8185116 | 0.92 | MMP13 (0.58) | MMP13MMP8MMP10MMP9HCRTR1 | |
| SCHEMBL10165651 | 0.92 | MMP13 (0.46) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL10162464 | 0.91 | MMP13 (0.53) | MMP13MMP8MMP10MMP9HCRTR1 | |
| SCHEMBL10162426 | 0.91 | MMP13 (0.53) | MMP13MMP8MMP10MMP9HCRTR1 | |
| SCHEMBL8185121 | 0.90 | MMP13 (0.56) | MMP13MMP8MMP10MMP9HCRTR1 | |
| SCHEMBL10165461 | 0.89 | MAPK1 (0.46) | MMP13PPARGWDR5 | |
| SCHEMBL14449876 | 0.87 | MMP13 (0.58) | MMP13MMP8MMP10MMP9ADAMTS4 | |
| SCHEMBL10162336 | 0.87 | MMP13 (0.49) | MMP13MMP8MMP10MMP9HCRTR1 | |
| SCHEMBL10162301 | 0.86 | MMP13 (0.53) | MMP13MMP8MMP10MMP9HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | MMP13 1/4885MMP8 26/4885MMP10 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.