Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165974 | 0.88 | MAPKAPK5 (0.49) | MAPKAPK5CCNKCCNA2CDK2CCND3 | |
| SCHEMBL1685146 | 0.87 | RAD52 (0.52) | ADRA2AADRA2CADRA2BMAPKAPK5MAPKAPK2 | |
| SCHEMBL1685214 | 0.79 | MAPKAPK5 (0.60) | ADRA2AADRA2CADRA2BMAPKAPK5MAPKAPK2 | |
| SCHEMBL13922407 | 0.78 | SMARCA2 (0.53) | ADRA2AADRA2CADRA2BMAPKAPK5MAPKAPK2 | |
| SCHEMBL1685153 | 0.77 | MAPKAPK5 (0.61) | ADRA2AADRA2CADRA2BMAPKAPK5JAK2 | |
| SCHEMBL1685141 | 0.74 | SYK (0.45) | ADRA2AADRA2CADRA2BMAPKAPK5MAPKAPK2 | |
| SCHEMBL1674183 | 0.74 | MAPKAPK5 (0.63) | MAPKAPK5EGFR | |
| SCHEMBL1685152 | 0.73 | MAPKAPK5 (0.49) | MAPKAPK5MAPKAPK2CCNKCCNA2CDK2 | |
| SCHEMBL13922505 | 0.73 | MAPT (0.55) | MAPKAPK5 | |
| SCHEMBL13922252 | 0.72 | SYK (0.41) | MAPKAPK5MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010206-A1 | IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS N. V. (BE) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010206-A1 | IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | COL2A1, MMP1, COL1A1 | ADRA2A 2711/4885ADRA2C 2276/4885ADRA2B 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.