Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALPG | P10696 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20399497 | 0.86 | PTGS2 (0.45) | IGF1RHSD17B10KDM4EMAPK1POLB | |
| SCHEMBL13209836 | 0.86 | IGF1R (0.45) | IGF1RHSD17B10KDM4EMAPK1POLB | |
| SCHEMBL12766044 | 0.83 | PTGS2 (0.60) | HSD17B10KDM4EMAPK1POLBMEN1 | |
| SCHEMBL20399726 | 0.82 | TRPA1 (0.43) | HSD17B10KDM4EMEN1KMT2ATSHR | |
| SCHEMBL1250655 | 0.80 | TSHR (0.50) | HSD17B10MEN1KMT2ATSHRMAPT | |
| SCHEMBL19732196 | 0.79 | HSD17B10 (0.48) | IGF1RHSD17B10KDM4EMAPK1POLB | |
| SCHEMBL16330250 | 0.79 | LMNA (0.41) | HSD17B10TSHRMAPTGAATP53 | |
| SCHEMBL23921372 | 0.78 | TRPV1 (0.39) | KDM4ETSHRTP53THRBALDH1A1 | |
| SCHEMBL14178749 | 0.78 | PTGS2 (0.42) | IGF1RKDM4EPOLBMEN1KMT2A | |
| SCHEMBL6833641 | 0.76 | TRPV1 (0.37) | IGF1RPOLBALPGMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040706-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-8980837-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8907092-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-1778718-B1 | INHIBITORS OF IAP | GENENTECH INC (US) | 2014-10-08 | — | — | EP | disclosed |
| US-8835393-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-20120270886-A1 | INHIBITORS OF IAP | KOEHLER MICHAEL F T (US) | 2012-10-25 | — | — | US | disclosed |
| US-8247557-B2 | IAP inhibitors | GENENTECH, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-8247557-B2 | IAP inhibitors | GENENTECH, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20120202750-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| WO-2008134679-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| US-20080146808-A1 | AZABICYCLO-OCTANE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146808-A1 | AZABICYCLO-OCTANE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| US-7345081-B2 | Azabicyclo-octane inhibitors of IAP | GENENTECH, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345081-B2 | Azabicyclo-octane inhibitors of IAP | GENENTECH, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-20070299052-A1 | Inhibitors of IAP | GENENTECH, INC. (US) | 2007-12-27 | — | — | US | disclosed |
| US-20070299052-A1 | Inhibitors of IAP | GENENTECH, INC. (US) | 2007-12-27 | — | — | US | disclosed |
| WO-2007106192-A2 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2007-09-20 | — | — | WO | disclosed |
| US-7244851-B2 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244851-B2 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146808-A1 | AZABICYCLO-OCTANE INHIBITORS OF IAP | XIAP, BIRC3, BIRC2 | IGF1R 267/4885HSD17B10 2850/4885KDM4E 3366/4885 |
| US-20070299052-A1 | Inhibitors of IAP | XIAP, BIRC5, BIRC3 | IGF1R 186/4885HSD17B10 4717/4885KDM4E 2538/4885 |
| US-20120202750-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | IGF1R 186/4885HSD17B10 4717/4885KDM4E 2538/4885 |
| US-20120270886-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | IGF1R 465/4885HSD17B10 4764/4885KDM4E 2296/4885 |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | IGF1R 480/4885HSD17B10 4793/4885KDM4E 1788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.