Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165309 | 0.92 | PHGDH (0.48) | PHGDHALDH1A1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL10165300 | 0.91 | PHGDH (0.46) | PHGDHALDH1A1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL10165315 | 0.88 | MMP13 (0.47) | PHGDHALDH1A1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL10166558 | 0.86 | MYC (0.47) | ALDH1A1CACNA1GCACNA1HCACNA1IHSD17B10 | |
| SCHEMBL10165311 | 0.80 | MYC (0.46) | ALDH1A1CACNA1GCACNA1HCACNA1IMMP13 | |
| SCHEMBL10166269 | 0.79 | MYC (0.49) | ALDH1A1CACNA1GCACNA1HCACNA1IMMP13 | |
| SCHEMBL10166579 | 0.79 | MYC (0.49) | ALDH1A1CACNA1GCACNA1HCACNA1IMMP13 | |
| SCHEMBL10165301 | 0.78 | MYC (0.50) | ALDH1A1CACNA1GCACNA1HCACNA1IHSD17B10 | |
| SCHEMBL10167297 | 0.78 | MMP13 (0.60) | PHGDHMMP13METKDM4EPPARG | |
| SCHEMBL10167300 | 0.76 | MMP13 (0.63) | PHGDHCACNA1GCACNA1HCACNA1IMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | PHGDH 2467/4885ALDH1A1 1806/4885CACNA1G 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.