Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | CDK1 | P06493 | 5/20 | 0.49 |
| ▸ | SRC | P12931 | 5/20 | 0.49 |
| ▸ | GSK3A | P49840 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.49 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | FYN | P06241 | 4/20 | 0.49 |
| ▸ | LYN | P07948 | 4/20 | 0.49 |
| ▸ | RET | P07949 | 4/20 | 0.49 |
| ▸ | ROS1 | P08922 | 4/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.49 |
| ▸ | MARK3 | P27448 | 4/20 | 0.49 |
| ▸ | TYK2 | P29597 | 4/20 | 0.49 |
| ▸ | FLT4 | P35916 | 4/20 | 0.49 |
| ▸ | FRK | P42685 | 4/20 | 0.49 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342867 | 0.98 | GSK3A (0.48) | KDRCDK1SRCGSK3AGSK3B | |
| SCHEMBL10167385 | 0.78 | BTK (0.45) | KDRCDK1SRCGSK3AGSK3B | |
| SCHEMBL342357 | 0.77 | AURKA (0.52) | CDK1AURKAAURKBBTKCCNB1 | |
| SCHEMBL10167410 | 0.77 | AURKA (0.52) | CDK1AURKAAURKBBTKCCNB1 | |
| SCHEMBL10167393 | 0.77 | EGFR (0.45) | KDRCDK1SRCGSK3AGSK3B | |
| SCHEMBL343811 | 0.76 | AURKA (0.51) | CDK1AURKAJAK2FGFR1AURKB | |
| SCHEMBL15428704 | 0.75 | CDK1 (0.48) | KDRCDK1SRCGSK3AGSK3B | |
| SCHEMBL15428705 | 0.75 | CDK1 (0.48) | KDRCDK1SRCGSK3AGSK3B | |
| SCHEMBL343868 | 0.74 | CDK1 (0.41) | KDRCDK1SRCGSK3AGSK3B | |
| SCHEMBL343043 | 0.74 | MERTK (0.42) | KDRCDK1SRCGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | disclosed |
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
| WO-2011156698-A2 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | CHUK, MAP2K2, CDK3 | KDR 3351/4885CDK1 10/4885SRC 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.